Valproate brand name in nz

Any mother would be shocked to discover her children were disabled. For Denise Astill, it was not just shock but also guilt. When her twin daughters, Jazmyn and Natasha, were diagnosed with foetal valproate syndrome FVS at the age of four, she discovered the likely cause was a drug she had taken during pregnancy.

After everything we had been through to conceive them - and then this happens. Epilim is an anti-epilepsy drug manufactured by pharmaceuticals giant Sanofi. Since the emergence of new research inMinistry of Health regulator MedSafe has published a warning on its website: "Like most medicines of this kind, Epilim may affect your developing baby if taken in the first trimester of pregnancy, as it is suspected of causing an increased risk of malformations in the exposed foetus.

Also, children born to mothers who take Epilim throughout their pregnancy may be at risk of impaired cognitive development or withdrawal syndrome. But even beforethere was clear evidence of the drug's dangers - evidence that parents say was not passed on to young women considering starting families.

Denise and her husband, Cameron, adore Jazmyn and Natasha but wish they had been told more about the risk of having babies with birth defects caused by Epilim.

valproate brand name in nz

The girls have developmental and physical problems and will need support for the rest of their lives. Sodium valproate - trade name Epilim - is an anti-epileptic drug also used for other conditions such as bipolar disorder, pain and migraines.

It has been compared to thalidomide after studies showed women on high doses have around a 20 per cent chance of having a baby with a range of defects such as different-looking facial features, neurodevelopmental delays including autism, a lower IQ and physical disabilities.

These defects are recognised clinically as FVS. The figures come from the Australian Pregnancy Register New Zealand has no formal register and its data shows 6 per cent of women on a low dose will have a baby with birth defects.

The risk increases to 50 per cent in a woman taking Epilim if she already has a child with birth defects. The syndrome is causing so much concern worldwide that the European Medicines Agency is reviewing all data on the benefits versus risks of using Epilim in pregnant women. The responsibility to inform women about these potential birth defects lies with the doctor who prescribes it, but there is concern that women who have been taking the medication long-term may not have been told of the risk when younger, or have not fully understood the seriousness of the warning.

There's also a fear that some doctors are not emphasising enough the potentially lifelong effects of Epilim on foetuses.

Now, medical specialists and some parents of children who have the syndrome are urging health authorities to put blunt warnings on all the packets, and include a brief and easy-to-read patient information sheet. An estimated women of child-bearing age are taking medication for epilepsy in New Zealand, and others for different reasons. These children will be under ACC care for the rest of their lives. It's likely more people are receiving ACC support for this syndrome, but before it was categorised under medical misadventure and was not recognised as FVS so the figures are not available.

The number of ACC claims for this syndrome is expected to increase as more cases are diagnosed, says Denise Astill. These pregnant women aren't being fully informed and something needs to change.

UK parents took legal action against Sanofi, on behalf of more than children whose mothers allege they suffered birth defects because the drug was taken during pregnancy. The case was publicly funded by legal aid through the Legal Services Commission, and the lawyers claimed they had evidence proving Sanofi was responsible for the injuries, and was liable for compensation.

Claimants alleged that if Sanofi had adequately warned them about the drug's risks, they would have chosen other treatment options. But public legal aid funding was withdrawn on the grounds it was available only in a small number of personal injury cases and, as a result, the claimants had to withdraw their case. In the United States, Epilim is sold under the brand name Depakote.Easy-to-read medicine information about sodium valproate — what it is, how to take sodium valproate safely and possible side effects.

Valproate works by blocking certain kinds of nerve activity. In New Zealand, valproate is available as:. Like all medicines, valproate can cause side effects; often side effects improve with time as your body gets used to the new medicine.

Valproate interacts with some other medications and herbal supplements, so check with your doctor or pharmacist before starting sodium valproate or before starting any new medicines. Do not take indigestion medication antacids within 2 hours of taking sodium valproate.

Looking for Where to get medical help A health professional or service Patient portals Newsletters View all. Sounds like 'val-PRO-ate'. Clearly document your review and discussion.

Advise female patients of the importance of planning a pregnancy in consultation with a doctor or specialist. In the event of an unplanned pregnancy while taking antiepileptic medicines, advise your patient to continue their medicines, and that you will seek urgent specialist advice.

However, poor adherence is reported in up to half of patients with epilepsy.

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Advise the patient to stop treatment and seek medical attention if dermatological, liver or haematological-related adverse effects develop. Patients should seek medical advice if they develop fever, infection, rash, abdominal pain, vomiting, yellowing of the skin, bruising or bleeding. Reproductive endocrine disorders, e.

Weight-bearing exercise can improve balance and bone strength. Measure the right amount using an oral syringe or medicine spoon. You can get these from your pharmacy. Do not use a kitchen spoon as it will not give you the right amount. Swallow the food or drink straight away. These are called enteric-coated EC tablets and are designed to prevent the medicine from upsetting the stomach.Valproate VPA and its valproic acidsodium valproateand valproate semisodium forms are medications primarily used to treat epilepsy and bipolar disorder and prevent migraine headaches.

Common side effects of valproate include nausea, vomiting, sleepiness, and dry mouth. Valproate's precise mechanism of action is unclear. Valproate was first made in and came into medical use in Valproic acid VPA is an organic weak acid. The conjugate base is valproate.

The sodium salt of the acid is sodium valproate and a coordination complex of the two is known as valproate semisodium. It is used primarily to treat epilepsy and bipolar disorder. It is also used to prevent migraine headaches. Valproate has a broad spectrum of anticonvulsant activity, although it is primarily used as a first-line treatment for tonic—clonic seizuresabsence seizures and myoclonic seizures and as a second-line treatment for partial seizures and infantile spasms.

Valproate products are also used to treat manic or mixed episodes of bipolar disorder. A systematic review compared the efficacy of valproate as an add-on for people with schizophrenia : [18].

Based upon five case reports, valproic acid may have efficacy in controlling the symptoms of the dopamine dysregulation syndrome that arise from the treatment of Parkinson's disease with levodopa. Valproate is also used to prevent migraine headaches. Because this medication can be potentially harmful to the fetus, valproate should be considered for those able to become pregnant only after the risks have been discussed.

The medication has been tested in the treatment of AIDS and cancerowing to its histone-deacetylase-inhibiting effects. Most common adverse effects include: [22]. Serious adverse effects include: [22].

valproate brand name in nz

Valproic acid has a black box warning for hepatotoxicitypancreatitisand fetal abnormalities. There is evidence that valproic acid may cause premature growth plate ossification in children and adolescents, resulting in decreased height. Studies have shown this risk of PCOS is higher in women with epilepsy compared to those with bipolar disorder. Valproate causes birth defects; [31] exposure during pregnancy is associated with about three times as many major abnormalities as usual, mainly spina bifida with the risks being related to the strength of medication used and use of more than one drug.

Children of mothers taking valproate during pregnancy are at risk for lower IQs. However, further research in older children and adults is needed. Sodium valproate has been associated with paroxysmal tonic upgaze of childhood, also known as Ouvrier—Billson syndrome, from childhood or fetal exposure. This condition resolved after discontinuing valproate therapy.

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Women who intend to become pregnant should switch to a different medication if possible, or decrease their dose of valproate. Studies have shown that taking folic acid supplements can reduce the risk of congenital neural tube defects.Back to Medicines A to Z. Sodium valproate is used to treat epilepsy and bipolar disorder. This medicine is only available on prescription. It also comes as granules that you mix with food or drink. It's not recommended for girls or women who may become pregnant.

Your doctor will put you on Prevent, the valproate pregnancy prevention programme.

valproate brand name in nz

While everyone is staying at home as much as possible, it can be hard to know what to do if you need medical help. If you are taking sodium valproate, get advice now if you think you are pregnant or might become pregnant. The valproate pregnancy prevention programme is important and is still running. Your doctor or nurse will talk to you on a video call or phone call.

They can also arrange safe visits to see you, if you need them to. If you usually have an annual review with your specialist, this can also be done as a video or phone call. Do not delay this important appointment.

If you're pregnant, do not take sodium valproate to treat bipolar disorder or to prevent migraines. This is because sodium valproate can seriously harm an unborn child. For treating epilepsy during pregnancy, your doctor will only prescribe sodium valproate for you if no other treatments work. Sodium valproate is a prescription medicine. It's important to take it as advised by your doctor. If your doctor tells you to take sodium valproate twice a day, you'll usually take half in the morning and half in the evening to make up your full daily dose.

If you're taking sodium valproate and also have kidney problems, your doctor may prescribe a lower dose. With "prolonged release" or "sustained release" sodium valproate, the medicine is released gradually into your body.

With "gastro resistant" tablets, the medicine is released as soon as it passes through your stomach. This means the sodium valproate gets into your body more quickly. Prolonged release tablets and capsules — swallow these whole with a drink of water or juice. Do not chew them. You'll usually take these once a day — unless you're on a high dose and your doctor tells you to take your medicine twice a day.

Valproate sodium

Prolonged release granules — add the granules to a small drink, then stir and swallow. If your prefer, sprinkle the granules onto any soft food that you can swallow whole. Do not chew the granules. Your doctor will tell you to take these either once or twice a day. Gastro resistant tablets — swallow these whole with a drink of water or juice. You'll usually take these twice a day.If you cannot find the information you are looking for, or have any queries about this information, please contact the pharmaceutical company named as the sponsor in the data sheet or CMI.

Commercial Use: Permission must be obtained from the sponsors pharmaceutical companies of the medicines concerned.

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CMI is useful information about your medicine and is written especially for you. CMI contains advice such as what the medicine is used for, how it should be taken, what side effects can occur, whether you can drive or drink alcohol while taking the medicine, and what to do if you miss a dose. However, CMI do not contain all the available information about the medicine.

Ask your doctor or pharmacist if you have any questions or concerns about taking the medicine.

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Pharmaceutical companies are responsible for producing CMI. However, in New Zealand there are no legal requirements for them to do so. The CMIs that are on this website have been written by pharmaceutical companiesusing Guidelines set by Medsafe.

The companies self-assess what information goes in each CMI against the requirements of the Guidelines. Each month, more CMIs are added to this website. If you cannot find a CMI for your medicine, it is most likely because the pharmaceutical company that makes or distributes your medicine has not yet written the CMI. Your doctor or pharmacist should be able to provide you with the information you need. Patients have the right to treatment that meets appropriate ethical and professional standards, including the right to be fully informed about the risks and benefits relating to efficacy and safety of medicines.

Who Writes CMI? Can't Find a CMI? Consumers' Rights Patients have the right to treatment that meets appropriate ethical and professional standards, including the right to be fully informed about the risks and benefits relating to efficacy and safety of medicines.Exfoliative dermatitis or erythroderma is a skin condition where the skin becomes reddened and inflamed accompanied by severe itching and peeling of the skin.

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Information about drug Sodium Valproate combination includes cost of the drug and the type of drug - tablet, capsule, syrup, cream, gel, ointment, liquid or injection. To view the price of the drug, click on the brand name. The generic Sodium Valproate combination is manufactured by one company. Medindia's drug directory has currently 26 Brands of Sodium Valproate listed. New generics and brands are constantly being updated as and when they are approved by drug controller and available in the pharmacies.

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Diaphragmatic Hernia. Recommended Reading. Exfoliative Dermatitis Exfoliative dermatitis or erythroderma is a skin condition where the skin becomes reddened and inflamed accompanied by severe itching and peeling of the skin. What's New on Medindia. Search Drugs.Drug information provided by: IBM Micromedex.

Valproic acid is used to treat certain types of seizures epilepsy. This medicine is an anticonvulsant that works in the brain tissue to stop seizures. Valproic acid is also used to treat the manic phase of bipolar disorder manic-depressive illnessand helps prevent migraine headaches.

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